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Effect of inhibiting UPS on Pdx1 protein stability. Graphs show the decline in fluorescence intensity for (a) mouse Pdx1 and (b) sand rat Pdx1 in cells treated with DMSO (control) or 10-µM MG132 (inhibitor of UPS), in both cases showing shift of protein decay curve. Statistical modeling confirmed that in both cases the effect is significant (mouse P = 1e-04; sand rat P = 0.0007); the Pdx1 protein half-lives were extended by 10.8 ± 0.9 h (mouse) and 11.3 ± 1.7 h (sand rat).
