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NOS inhibitors prevent LTP induction by prolonged stimulation at 30 Hz. Delivery of 900 pulses at 30 Hz in control ACSF (open circles) produces LTP of the field EPSP slope. The same tetanus delivered in the presence of 100 μm NOArg leads to only short-term potentiation. Slices were exposed to NOArg for at least 30 min before tetanus and throughout the post-tetanus measurement period.
