Fig. 8.
Upregulation of the lysosomal pathway inTrJ/+ mice. Total sciatic nerve homogenates of 18-d-old (P 18) wild-type (+/+), heterozygous (+/−), homozygous (−/−), and adult wild-type (+/+) and heterozygous (+/−) mice were analyzed for the expression of LAMP1 and protein hydrolase CatD. Arrows point to LAMP1 and the 48 kDa precursor and 34 kDa mature forms of CatD. The open arrow indicates a nonspecific band that is immunoreactive against the polyclonal anti-CatD antibody. All lanes contain 25 μg of total protein. Molecular weights are indicated in kilodaltons.