Fig. 3.

Temperature-sensitive evoked CGRP release. The top panel describes the basal outflow of CGRP over all temperatures investigated (8, 18, 25, 34, 37, and 40°C). Temperature dependency of potassium (•)- and capsaicin (○)-evoked CGRP release is shown in the bottom panelas a plot of temperature (°C) versus percentage change from basal release. Statistically significant increases from baseline are indicated by * (p < 0.05) or ** (p < 0.01). Hyperthermia produced significant increases in evoked release relative to normothermia, as indicated by † (p < 0.02) and ‡ (p < 0.0001).