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. 1997 Jun 1;17(11):4066–4075. doi: 10.1523/JNEUROSCI.17-11-04066.1997

Fig. 5.

Fig. 5.

Somatostatin receptors inhibit mEPSCs in hippocampal mass culture neurons. A, MEPSCs were recorded in a mass culture neuron at −70 mV in 1 sec sweeps in the presence of 1 μm TTX and 30 μm BMI. More than 200 events were evaluated from recordings obtained before (control), during, and after (wash) the application of 1 μmsomatostatin. The distribution of mEPSC amplitudes (A1) and inter-mEPSC intervals (A2) is shown. B, Effects of 1 μm of somatostatin, seglitide, and octreotide on mean mEPSC amplitudes and mean inter-mEPSC intervals of five to six mass culture neurons. Results are shown as percentage of control. Changes in mean intervals (>50 events for each condition) were significant (p < 0.05) in each neuron.C, Effects of somatostatin on mEPSCs recorded as inA and B, but in the presence of 100 μm Cd2+ (n = 5). Changes in mean intervals were significant (p < 0.05) in each neuron. D, Effects of somatostatin on mEPSCs recorded as in A–C, but in neurons treated for ≥24 hr with 200 ng/ml PTX (n = 5). Note the loss of somatostatin effects.