Table 2.
Effects of multiple amphetamine runs on caudate-putamen and nucleus accumbens dopamine levels (pmol/gm tissue)
| Caudate-putamen | Nucleus accumbens | |
|---|---|---|
| Saline (6) | 99.0 ± 5.2 | 37.1 ± 2.7 |
| Acute (6) | 96.3 ± 3.0 | 32.0 ± 2.3 |
| ED/Run 1 (6) | 83.1 ± 6.4 | 38.0 ± 2.4 |
| ED/Run 9 (5) | 60.0 ± 9.32-160 | 35.6 ± 2.0 |
Tissue levels were determined in groups of animals (numbers in parentheses) 4 d after the indicated treatment regimen. (Caudate-putamen ANOVA: F = 8.01, p < 0.001).
F2-160: p < 0.01 (t = 4.03) compared with the Acute group.