Fig. 1.

Mean (±SEM) 30 min food intake after bilateral microinjections of various doses of GABA agonists and antagonists into the AcbSh. a, Intake was increased significantly with all doses of baclofen tested and with all doses of muscimol over 88 pmol. b, As demonstrated in the previous experiment, injection of 188 ng of baclofen significantly increased food intake (p < 0.01). The baclofen-induced feeding was eliminated by coadministration of 500 ng of the selective GABA_B antagonist saclofen, but was not affected by 75 ng of the GABA_A antagonist bicuculline. c, In a separate group of rats, 50 ng of muscimol significantly increased food intake (p < 0.01), and this increase was abolished by coadministration of 75 ng of bicuculline. Coadministration of 500 ng saclofen had no effect on the feeding elicited by muscimol. Symbols denote significant increases in intake as compared with saline treatment. *p < 0.05; †p < 0.01; ‡p < 0.001.