Fig. 2.

Effects of intraperitoneal administration of saline (A) and LPS (B) (100 μg/kg body weight) on body temperature in long-term intracerebroventricularly vehicle-treated rats (•) and intracerebroventricularly CRH-infused rats (○). Saline or LPS were injected at 11:30 A.M. on day 7 of the infusion treatment, as indicated by the arrow. Body temperature (δ baseline) was monitored during 24 hr starting at 7:30 A.M. on day 7. For more details see Materials and Methods. Thetime points on the x-axis correspond to the time of the day at which collection of the 30 min sample was started. The shaded area indicates the dark period. Values represent mean ± SEM (intraperitoneally saline-injected groups, n = 3; intraperitoneally LPS-injected groups, n = 5). *, Significantly different from intracerebroventricularly vehicle-treated rats (MANOVA with repeated measures design). For additional statistical analyses, see Results.