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. 1997 Jun 1;17(11):4448–4460. doi: 10.1523/JNEUROSCI.17-11-04448.1997

Table 1.

Effect of long-term administration of CRH on body weight gain and thymus weight

Intracerebroventricular vehicle (n = 26) Intracerebroventricular CRH (n = 21) Subcutaneous CRH (n = 10)
Body weight gain (gm) 25.2  ± 4.2 −9.0  ± 3.4*,1-159 23.9  ± 4.0
Thymus weight (mg) 596.3  ± 30.4 243.5  ± 14.0* 297.4  ± 44.6*

CRH (1 μg · μl−1 · hr−1) was infused into rats either intracerebroventricularly or subcutaneously. Control animals were treated intracerebroventricularly with vehicle (1 μl/hr). To avoid disturbance of the animals on the day of the endotoxin-challenge experiment (day 7), body weights were measured on day 6. Animals were killed on day 8 and thymus weights were determined. The number of rats in each experimental group is in parentheses. Data are mean ± SEM (data from Protocols A and B; for further details see Materials and Methods).

*

p < 0.05 compared with vehicle-treated rats;

F1-159: p < 0.05 compared with subcutaneous CRH-treated rats (Duncan multiple range test).