Table 1.
Intracerebroventricular vehicle (n = 26) | Intracerebroventricular CRH (n = 21) | Subcutaneous CRH (n = 10) | |
---|---|---|---|
Body weight gain (gm) | 25.2 ± 4.2 | −9.0 ± 3.4*,1-159 | 23.9 ± 4.0 |
Thymus weight (mg) | 596.3 ± 30.4 | 243.5 ± 14.0* | 297.4 ± 44.6* |
CRH (1 μg · μl−1 · hr−1) was infused into rats either intracerebroventricularly or subcutaneously. Control animals were treated intracerebroventricularly with vehicle (1 μl/hr). To avoid disturbance of the animals on the day of the endotoxin-challenge experiment (day 7), body weights were measured on day 6. Animals were killed on day 8 and thymus weights were determined. The number of rats in each experimental group is in parentheses. Data are mean ± SEM (data from Protocols A and B; for further details see Materials and Methods).
p < 0.05 compared with vehicle-treated rats;
F1-159: p < 0.05 compared with subcutaneous CRH-treated rats (Duncan multiple range test).