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Effect of high frequency stimulation on synaptic responses. Plots of the response to high frequency tetanic stimulation (100 pulses at 50 Hz; stimulation at 4× threshold) in the CA1 pyramidal cell region of wild-type (NPY+/+) and NPY-deficient (NPY−/−) mice. They-axis shows population spike amplitude plotted as the percent of initial response (normalized to 100%). Representative extracellular field recordings are shown in insets. Calibration, 5 mV, 20 msec.
