Fig. 5.

Huntingtin (HDp549) immunoreactivity in the dorsal (A) and ventral (B) striatal matrix of the caudate nucleus. Huntingtin immunoreactivity is present in medium-sized neurons and is confined to the cytoplasm. Marked variability in neuronal immunoreactive intensity is observed. Neurons are immunolabeled either darkly (arrowheads) or lightly (arrows) for huntingtin (see Fig. 3C,D). The more darkly immunostained neurons are significantly greater in diameter (see Results). Magnification bars in A,B, 200 μm.