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. 1997 May 1;17(9):2959–2966. doi: 10.1523/JNEUROSCI.17-09-02959.1997

Fig. 2.

Fig. 2.

BDNF did not affect non-NMDA-type glutamate receptor-mediated EPSCs. A, Recording of the CNQX-sensitive EPSCs from voltage-clamped (−60 mV) CA1 pyramidal neurons. Stimulation of Schaffer collaterals produced the inward currents sensitive to 20 μm CNQX in the presence of 20 μm bicuculline. Representative traces are shown as the average of eight consecutive responses (calibration: 25 pA, 30 msec).B, Effect of BDNF on evoked EPSCs. BDNF (100 ng/ml, 15 min) did not significantly affect non-NMDA-type glutamate receptor-mediated EPSCs (right). Each trace represents the averaged EPSCs of eight consecutive sweeps (calibration: 40 pA, 30 msec). C, The time courses of changes in EPSCs. BDNF tended to increase the amplitude of EPSCs transiently (within 2 min) but had no significant effect on subsequent EPSCs. Data are indicated as mean ± SEM (n = 6).