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Reduction of the amplitude, but not the frequency, of spontaneous IPSCs by BDNF. BDNF (50 ng/ml, 15 min) reduced the amplitude, but not the frequency, of spontaneous IPSCs (lower traces). B, Summarized histograms from the data shown in A. BDNF caused a slight leftward shift in the amplitude distribution, reflecting a decrease in the mean size of these events. Data were sampled for 200 sec in the absence (left) or presence (right) of 50 ng/ml BDNF.
