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. 1997 May 15;17(10):3623–3633. doi: 10.1523/JNEUROSCI.17-10-03623.1997

Fig. 3.

Fig. 3.

Neurons in trkB (−/−) mice die by apoptosis. A, B, Immunolabeling with c-Jun antibody reveals the presence of pyknotic cells in layers II and III (A) and degenerating neurons in the pyriform cortex (B) in P10 trkB (−/−) mice.C, Electron micrograph showing the characteristic morphology of an apoptotic cell in the dentate gyrus that is being engulfed by a neighboring cell in a trkB (−/−) mouse.D–G, TUNEL staining of neocortex (layers II and III) (D, E) and hippocampus (F, G); sections from P13 control (D, F) and trkB (−/−) (E, G) mice. Notice the increase in TUNEL-positive nuclei in the trkB (−/−) mice.Arrows in A denote pyknotic nuclei. Thearrowhead denotes a pyknotic nucleus negative for c-Jun staining. Sections in A and B are counterstained with cresyl violet. GL, Granular layer;H, hilus; ML, molecular layer. Magnification: A, B, 30×; C, 15,000×;D–G, 40×.