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. 1997 May 15;17(10):3623–3633. doi: 10.1523/JNEUROSCI.17-10-03623.1997

Fig. 4.

Fig. 4.

Expression of calcium-binding proteins in degenerating neurons in trkB (−/−) mutant mice.A–D, Calretinin immunoreactivity in layers II and III of the neocortex (A, B, D) and the stratum oriens of the hippocampus (C) of P10 trkB (−/−) mutant mice. Presumably, degenerating neurons with atrophic somata and beaded dendrites are immunoreactive for calretinin staining (A, B, arrows). E, Calbindin expression in layers II and III of the neocortex of a P13 trkB (−/−) mice. Arrows in C–E denote pyknotic cells immunoreactive for different calcium-binding proteins.Arrowheads denote unlabeled pyknotic cells. Sections are counterstained with cresyl violet. Magnification: A, B,35×; C, D, 40×; E, 45×.