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. 1997 May 15;17(10):3503–3514. doi: 10.1523/JNEUROSCI.17-10-03503.1997

Fig. 7.

Fig. 7.

Recovery from inactivation has multiple components in control neurons. A, Data from a typical control C-type neuron are shown. The cell was held at −100 mV, stepped to 0 mV for 20 msec to inactivate channels, and then brought back to −100 mV for increasing durations before the test potential of 0 mV. Current traces shown in A correspond to specific time points in the recovery time course shown in B. The time course of recovery exhibited at least two components. The TTX-R component (traces1 and 2) recovered rapidly, with a time constant of 0.7 msec. The TTX-S component recovered slowly (traces5–7), with a time constant of 87 msec. C, Data from another control neuron are shown. The time course of recovery is shown for the total current (•) and for the separated TTX-R (□) and TTX-S components (▵). The TTX-R time course was obtained in the presence of 100 nm TTX. The TTX-S time course was obtained by subtracting the currents recorded with TTX from the data obtained without TTX.