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Axotomy increases the relative sensitivity of C-type neurons to frequency-dependent inhibition by lidocaine. Representative traces from a control (A) and DPA8 (B) neuron are shown. Cells were exposed to 50 μm lidocaine. After 5 min, the cells were stimulated with a 10 Hz train of 20 depolarizations (to 0 mV for 10 msec). The currents elicited by the first (solid trace) and 20th (dashed trace) depolarizations are shown.
