Fig. 4.

Cyclin B1 is present in neurons of AD brain. Hippocampal tissue sections from AD (top row), normal human (bottom row, left), and mouse brains (bottom row, right) were stained with human cyclin B1 monoclonal antibody. In some AD cases (AD1), staining of the neuronal cytoplasm and nucleus was observed, but in other cases, (AD2), primarily the neuronal nucleus (small arrows) and, occasionally, neurons (large arrow) were stained. Positive neuronal nuclei were also observed in some normal cases (shown), but not in mouse. Magnifications for the human and mouse illustrations are 150× and 75×, respectively.