Expression patterns in different subtypes of neocortical nonpyramidal cells. This histogram shows the distribution of the cells from each physiological subtype according to their CaBP expression and the occurrence of neuropeptides. +, Expression of at least one neuropeptide; −, none of the four neuropeptides expressed. Most of the fast spiking cells (FS, black bars) expressed PV, except four cells that expressed only CB. None of them expressed CR. Approximately half of the FS cells showed neuropeptide expression. Regular spiking nonpyramidal cells (RSNP, gray bars) displayed the most heterogeneous expression patterns. All of the biochemical markers studied have been detected in this cell type. Most of them expressed at least one neuropeptide. All irregular spiking cells (IS, hatched bars) expressed CR and VIP.