Fig. 1.

Glutamate, but not dopamine or forskolin, induces expression of a transfected 4× AP-1-luciferase fusion construct.A, Glutamate (Glu, 100 μm) and TPA (100 nm), but not dopamine (DA, 100 μm) or forskolin (F, 10 μm), activate transcription of a 4× AP-1 luciferase construct. Values for luciferase activity are given as fold induction, and data are represented as mean ± SEM percentage of transfected control values (n = 3). Background luciferase activity determined from untransfected controls was subtracted; *p < 0.05 compared with control group.B, The glutamate activation of AP-1 transcription is blocked by MK-801 (1 μm, added 10 min before glutamate); *p < 0.05 compared with control or glutamate plus MK-801 groups.