Table 1.
Modulation of GABAA receptor-mediated mIPSCs by acute perfusion of FRZ in CA1 and dentate gyrus (DG) hippocampal neurons
| CA1 | DG | |||
|---|---|---|---|---|
| Control | Acute FRZ | Control | FRZ | |
| Conductance (nS) | 0.69 ± 0.15 | 0.73 ± 0.26 | 0.62 ± 0.12 | 0.71 ± 0.11 |
| Decay time constant (msec) | 3.4 ± 0.6 | 7.6 ± 2.1* | 4.2 ± 0.6 | 7.1 ± 1.8* |
| 10–90% Rise time (msec) | 0.61 ± 0.10 | 0.62 ± 0.11 | 0.58 ± 0.06 | 0.63 ± 0.03 |
| Frequency (Hz) | 22.6 ± 7.0 | 18.7 ± 6.6 | 8.2 ± 4.7 | 7.4 ± 3.3 |
| Number of cells | 18 | 12 | 15 | 6 |
In both CA1 and DG, perfusion of FRZ (30 μm) produced prolongation of mIPSCs without affecting the mean conductance, 10–90% rise time, and frequency of occurrence. Values are expressed as mean ± SD. Asterisk indicates statistically significant differences (t test) with respect to the control at p< 0.0001. Values without asterisk are not significantly different from control at p > 0.05.