Table 3.

Alteration of the conductance (g) and frequency of occurrence (Fr.) of mIPSCs in CA1 neurons at different days of withdrawal (WD) after chronic FRZ treatment

	Control	WD2	WD3	WD4	WD5	WD6
g (nS)	0.78  ± 0.12	0.51  ± 0.18*	0.35  ± 0.03**	0.30  ± 0.09**	0.31  ± 0.05**	0.81  ± 0.06
Fr. (Hz)	22.9  ± 8.6	24.5  ± 8.1	7.8  ± 4.7*	4.8  ± 2.1**	4.1  ± 0.6**	17.8  ± 8.2
Number of cells	18	10	6	5	31	5

Massive reductions in the conductance and frequency of occurrence were observed between 3 and 5 d of withdrawal. Note that, after 2 d of withdrawal, only a decrease in mIPSC conductance was observed in CA1 neurons. Values are expressed as mean ± SD. Asterisks indicate statically significant differences (t test) from controls p < 0.01 (*) and p < 0.001 (**). Values without asterisks are not significantly different from controls (p > 0.05). During chronic BZ exposure, there were no differences between the doses of FRZ consumed by each animal.