Fig. 4.

Effect of prolonged administration of either saline (n = 5) or NT-3 (1 mg/kg, s.c., 3 times a week for 2 weeks; n = 7) on SP-LI release from the rat spinal cord in vitro. SP-LI release was evoked by electrical stimulation of the dorsal roots for 8 min (horizontal black bar) of spinal cord preparation isolated 24 hr after last injection of NT-3. *p < 0.05, Student’st test between femtomoles of SP-LI present in the stimulated fraction after subtraction of the basal outflow of control and NT-3-treated spinal cords (see Results). The areas under curves were not significantly different.