Table 1.
GLAST | GLT-1 | EAAC1 | EAAT4 | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E15 | E18 | P1 | P10 | P24 | Ad | E15 | E18 | P1 | P10 | P24 | Ad | E15 | E18 | P1 | P10 | P24 | Ad | E15 | E18 | P1 | P10 | P24 | Ad | |
Neocortex | ||||||||||||||||||||||||
Marginal zone | ± | ± | ± | ± | ++ | ++ | − | − | ||||||||||||||||
Layer 1 | ± | ± | + | + | ± | ++ | ++ | ++ | ++ | ++ | + | + | ± | ± | + | ± | ||||||||
Cortical plate | ± | − | ++ | − | ||||||||||||||||||||
Layer II | ± | ± | + | + | − | + | ++ | ++ | + | + | + | + | ± | ± | ± | ± | ||||||||
Layer III | ± | ± | + | + | − | + | ++ | ++ | ++ | + | + | + | ± | ± | + | ± | ||||||||
Layer IV | ± | ± | + | + | − | + | ++ | ++ | + | + | + | + | ± | ± | ± | ± | ||||||||
Layer V | ± | ± | + | + | − | + | ++ | ++ | ++ | + | + | + | ± | ± | + | ± | ||||||||
Layer VI | ± | ± | + | + | − | + | ++ | ++ | ++ | ++ | + | + | ± | ± | ± | ± | ||||||||
Intermediate zone | ± | ± | ± | − | ||||||||||||||||||||
Cerebral white matter | ± | ± | ± | + | ± | ± | + | + | ± | + | ± | ± | − | − | − | − | ||||||||
Ventricular and subventricular zones | ± | ± | + | ± | − | − | ± | − | ± | ± | ± | − | − | − | − | − | ||||||||
Hippocampus | ± | ± | − | + | ± | ++ | − | − | ||||||||||||||||
Stratum moleculare-lacunosum | ± | ± | + | + | + | + | ++ | ++ | ++ | + | + | + | − | ± | + | ± | ||||||||
Stratum radiatum | ± | ± | + | + | + | + | ++ | ++ | + | + | + | + | − | ± | + | ± | ||||||||
Stratum pyramidale | ± | ± | ± | ± | − | − | + | + | + | ++ | + | + | ± | ± | ± | ± | ||||||||
Stratum oriens | ± | ± | + | + | + | + | ++ | ++ | ++ | + | + | + | − | ± | + | ± | ||||||||
Granular layer | ± | ± | ± | ± | − | − | + | + | + | ++ | + | + | − | ± | ± | ± | ||||||||
Olfactory bulb | ± | ± | ± | ± | + | + | ± | ± | + | + | ++ | ++ | / | ± | + | + | + | + | − | − | − | ± | ± | ± |
Ganglionic eminence | ± | ± | + | − | − | ± | ± | ± | ± | − | − | − | ||||||||||||
Striatum | ± | ± | ± | ± | + | + | − | − | ± | + | ++ | ++ | ± | ++ | ++ | ++ | + | + | − | − | − | ± | + | ± |
Globus pallidus | ± | ± | ± | ± | + | + | − | + | ± | + | ++ | ++ | ± | ++ | + | + | + | + | − | − | − | − | ± | ± |
Septum | ± | ± | ± | ± | + | + | ± | ± | ± | + | ++ | ++ | ± | + | + | + | + | + | − | − | − | − | + | ± |
Amygdala | ± | ± | ± | ± | + | + | − | + | ± | + | ++ | ++ | ± | ++ | + | + | + | + | − | − | − | − | ± | ± |
Thalamus | ± | ± | ± | ± | ± | + | − | − | − | + | ++ | ++ | ± | ± | + | + | + | + | − | − | − | ± | ± | ± |
Hypothalamus | ± | ± | ± | ± | + | + | ± | + | + | + | ++ | ++ | ± | ± | + | + | + | + | − | − | − | − | − | − |
Tectum | ± | ± | ± | ± | ± | + | ± | + | ± | + | ++ | ++ | − | + | + | ++ | + | + | − | − | − | − | − | − |
Medulla oblongata | ± | ± | ± | ± | ± | ± | ± | + | + | + | + | + | + | + | + | ++ | ± | ± | − | − | − | − | − | − |
Cerebellar primordium | ± | ± | − | − | − | + | − | − | ||||||||||||||||
Cerebellar cortex | ||||||||||||||||||||||||
External granular layer | − | − | − | − | − | − | − | − | ||||||||||||||||
Molecular layer | + | ++ | ++ | ± | ++ | ++ | + | + | + | + | ++ | ++ | ||||||||||||
Purkinje cell layer | + | ++ | + | + | − | + | + | + | ++ | ++ | ++ | ++ | + | + | + | + | ||||||||
Internal granular layer | ± | ± | ± | ± | − | ± | + | + | − | + | + | + | − | − | − | − | ||||||||
Deep cerebellar nucleus | − | ± | ± | ± | + | + | + | + | + | ++ | + | + | − | ± | ± | − | ||||||||
Spinal cord | ||||||||||||||||||||||||
Posterior horn | ± | ± | + | + | + | + | ± | + | + | + | ++ | ++ | + | ++ | ++ | ++ | ++ | ++ | − | − | − | − | ± | ± |
Ventral horn | ± | ± | + | + | ± | ± | ± | + | + | + | + | + | + | ++ | ++ | ++ | ++ | ++ | − | − | − | − | − | ± |
White matter | − | − | ± | ± | ± | ± | ++ | ++ | + | + | + | + | − | ± | ± | + | + | + | − | − | − | − | − | − |
Ad, Adult. Symbols designate no detectable (−), faint (±), moderate (+), and high (++) levels of immunoreactivity and not examined (/).