Table 1.
Cases in the literature reported to develop CC after an established diagnosis of IBD
| Age at CC diagnosis (years)/gender | IBD type | Part of GI tract involved | Duration of IBD before CC diagnosis (years) | IBD medication at CC diagnosis | Duration of TNFα inhibitor before onset of CC (months) | Active vs remission at CC diagnosis | Other medications | Associated diseases | Medications used to treat CC | Outcome of CC | Reference | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | 49/Female | UC | Entire colon | 10 | Adalimumab | 66 | Remission | Rabeprazole, levothyroxine, glimepiride, metformin, ramipril, cetirizine, aspirin | Diabetes, Hashimoto’s thyroiditis, anxiety, GERD and multiple drug allergies | Cholestyramine and budesonide | Complete resolution | This report |
| Case 2 | 60/Female | CD | Esophagus, stomach, ileum and colon | 2 | Infliximab | 12 | Remission | Levothyroxine, sitagliptin phosphate/ metformin hydrochloride, pravastatin, lanzoprazole | Diabetes, hypothyroidism, diverticulosis and GERD | Cholestyramine | Complete resolution | This report |
| Case 3 | 35/Male | CD | Terminal ileum | NR | No medications | NA | Active | Indomethacin, ACEI, ARB, IV antibiotics, steroids | Nephrotic syndrome, Amyloidosis | NR | NR | [17] |
| Case 4 | 79/Female | UC | NR | 14 | Mesalamine | NA | Remission | NR | NR | Mesalamine | Complete resolution | [16] |
| Case 5 | 59/Female | UC | Left side of the colon | 13 | Mesalamine | NA | Remission | Ibuprofen (no association with CC symptoms) | NR | Bismuth | Complete resolution | [16] |
| Case 6 | 59/Female | CD | Perianal | NR | Infliximab | NR | Active | Mood stabilizers (in the past) | Depression, h/o acute steroid psychosis | Bismuth subsalicylate and imodium | Complete resolution | [20] |
| Case 7 | 63/Male | UC | Left side of the colon | 8 | Mesalamine | NA | Remission | NR | NR | NR | NR | [18] |
| Case 8 | 57/Female | UC | Entire colon | 5 | Mesalamine and prednisolone | NA | Remission | ACEI, Adriamycin, Cyclophosphamide, Etoposide, Melphalan | Systemic Amyloidosis, autologous stem-cell transplantation | NR | NR | [19] |
| Case 9 | 70/Female | CD | Entire colon | 5 | No medications | NA | Remission | NR | IDDM, Grave’s disease, atrophic gastritis | NR | NR | [21] |
NR, not reported; NA, not applicable; GI, gastrointestinal; IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease; CC, collagenous colitis; TNFαIs, tumor necrosis factor-α inhibitors; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; GERD, gastroesophageal reflux disease; IDDM, insulin-dependent diabetes mellitus.