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. Author manuscript; available in PMC: 2020 Jun 17.
Published in final edited form as: Angew Chem Int Ed Engl. 2019 May 10;58(25):8454–8457. doi: 10.1002/anie.201902910

Figure 3.

Figure 3.

LCMS analysis of DsKabA and DsKabC in vitro assays. Each trace represents the (M H)−extracted ion chromatogram for prekainic acid (214.1 ± 0.5 m/z) and kainic acid (212.1 ± 0.5 m/z). DsKabA converts l-Glu and DMAPP to prekainic acid in a Mg2+-dependent manner (purple traces). DsKabC can convert prekainic acid (PKA) to kainic acid (KA) and kainic acid lactone (KA Lactone), but turnover is nearly undetectable when the iron chelator EDTA is added (cyan traces).