Figure 2. Aurora inhibition results in aneuploidy and senescent cells (AASCs) responsible for treatment failure.

U2932 cells are treated with 50nM alisertib for 4 days and analyzed by flow cytometry show (A). Alisertib as a single agent induces cell death in ~30% of cells. (B) Aneuploid cell have an increase in cell size and are metabolically active. (C). Aneuploid cells form the major proportion of cells that avoid cell death. (D) Aneuploid cells are also representative of senescence.