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. Author manuscript; available in PMC: 2020 Feb 13.
Published in final edited form as: J Am Chem Soc. 2019 Jan 29;141(6):2435–2445. doi: 10.1021/jacs.8b11474

Figure 4.

Figure 4.

Predicted binding isotherm of cations within the GQ channel as a function of salt concentration (NaCl, shown in orange; KCl, shown in violet). A total of seven potential binding sites were identified for cations along the Oxy-GQ channel (see the section Recapitulating the Binding of Cations in the Oxy-GQ Central Channel), three of which are intercalated between G-quartet stacks, two that are marginal and bind with one G-quartet and Ts in the T4 loops, and two that are buried within the T4 loops. Binding isotherms are shown for the intercalated and marginal sites.