Comparison 1. Vaginal misoprostol versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Complete miscarriage	5	305	Risk Ratio (M‐H, Fixed, 95% CI)	4.23 [3.01, 5.94]
1.1 Complete miscarriage < 1 day	2	138	Risk Ratio (M‐H, Fixed, 95% CI)	4.73 [2.70, 8.28]
1.2 Complete miscarriage < 2 days	2	84	Risk Ratio (M‐H, Fixed, 95% CI)	5.74 [2.70, 12.19]
1.3 Complete miscarriage < 7 days	1	83	Risk Ratio (M‐H, Fixed, 95% CI)	2.99 [1.80, 4.99]
2 Death or serious complications: uterine perforation	1	84	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 7.96]
3 Blood transfusion	1	84	Risk Ratio (M‐H, Fixed, 95% CI)	0.2 [0.01, 4.04]
4 Blood loss: haemoglobin difference > 10 g/L	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.38, 4.12]
5 Days of bleeding: vaginal bleeding 2 weeks after treatment	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.41, 2.45]
6 Nausea	2	88	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [0.43, 4.40]
7 Diarrhoea	2	88	Risk Ratio (M‐H, Fixed, 95% CI)	2.21 [0.35, 14.06]
8 Pain (opiate use)	1	84	Risk Ratio (M‐H, Fixed, 95% CI)	5.0 [0.25, 101.11]
9 Woman's satisfaction with treatment	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	1.17 [0.83, 1.64]