Kara 1999*.
Methods | Quote: "Random allocation". No details. Zeynep Kamil Women and Childrens Hospital, Istanbul, Turkey. No information on study duration. |
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Participants | 65 women in Istanbul, Turkey, with ultrasound‐diagnosed fetal death in second trimester. | |
Interventions | Vaginal misoprostol 200 mcg (n = 32) vs intracervical dinoprostone 0.5 mg (n = 33). Intravenous oxytocin started after 6 hours if no 'effective contractions'. | |
Outcomes | Complete miscarriage. Adverse effects. | |
Funding | No information on funding. | |
Declarations of interest | No information on conflicts of interest. | |
Notes | Misoprostol dose reported as 200 mg. Assumed to be 200 mcg. Time to miscarriage not included as standard deviations seem incorrect. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Comment: quote: "Random allocation". No details. |
Allocation concealment (selection bias) | Unclear risk | Comment: no information on allocation concealment. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Comment: 65 patients were randomised, for all of them outcomes were presented, there seems to be no missing data. |
Selective reporting (reporting bias) | Low risk | Comment: misoprostol dose reported as 200 mg. Assumed to be 200 mcg. Other than these findings no signs of selective or unclear reporting. |
Other bias | Low risk | No other source of bias could be detected |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Comment: no information on blinding of participants and personnel, considering the type of intervention (different number and shape of tablets used) probably not done. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Comment: no information on blinding of outcome assessment, probably not done. |