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. 2019 Jun 17;2019(6):CD002253. doi: 10.1002/14651858.CD002253.pub4

Kara 1999*.

Methods Quote: "Random allocation". No details.
Zeynep Kamil Women and Childrens Hospital, Istanbul, Turkey. No information on study duration.
Participants 65 women in Istanbul, Turkey, with ultrasound‐diagnosed fetal death in second trimester.
Interventions Vaginal misoprostol 200 mcg (n = 32) vs intracervical dinoprostone 0.5 mg (n = 33). Intravenous oxytocin started after 6 hours if no 'effective contractions'.
Outcomes Complete miscarriage. Adverse effects.
Funding No information on funding.
Declarations of interest No information on conflicts of interest.
Notes Misoprostol dose reported as 200 mg. Assumed to be 200 mcg. Time to miscarriage not included as standard deviations seem incorrect.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: quote: "Random allocation". No details.
Allocation concealment (selection bias) Unclear risk Comment: no information on allocation concealment.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: 65 patients were randomised, for all of them outcomes were presented, there seems to be no missing data.
Selective reporting (reporting bias) Low risk Comment: misoprostol dose reported as 200 mg. Assumed to be 200 mcg. Other than these findings no signs of selective or unclear reporting.
Other bias Low risk No other source of bias could be detected
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: no information on blinding of participants and personnel, considering the type of intervention (different number and shape of tablets used) probably not done.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: no information on blinding of outcome assessment, probably not done.