Tang 2003.

Methods	Randomisation by quote: "computer‐generated random numbers". Queen Mary Hospital, Hong Kong SAR, China. No information on study duration.
Participants	80 women with non‐viable pregnancies diagnosed by ultrasound < 13 weeks.
Interventions	Group 1: 600 mcg misoprostol sublingually every 3 hours for maximum of 3 doses (n = 40); group 2: 600 mcg misoprostol vaginally every 3 hours for maximum of 3 doses (n = 40). Women discharged home after completion of treatment and reassessed day 7 ‐ when surgical evacuation performed if gestation sac still present, or retained POC plus heavy bleeding.
Outcomes	Primary outcome: complete miscarriage (defined as no need for surgical evacuation up until return of menstruation).
Funding	No information on funding.
Declarations of interest	No information on conflicts of interest.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Comment: computer‐generated random numbers.
Allocation concealment (selection bias)	Unclear risk	Comment: no information on allocation concealment.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: outcomes were presented for all 80 patients that were initially randomised.
Selective reporting (reporting bias)	Unclear risk	Comment: table 3 shows several side effects. The methods section states only that 'side effects' were measured without further specification. It is unclear if other side effects than the ones presented in table 3 were also measured.
Other bias	Low risk	No other source of bias could be detected
Blinding of participants and personnel (performance bias) All outcomes	High risk	Comment: no blinding of participants and personnel. Sublingual misoprostol was taken by the patient itself while vaginal misoprostol was administered by a research nurse.
Blinding of outcome assessment (detection bias) All outcomes	High risk	Comment: no information on blinding of outcome assessment. Probably not done.