Table S3.
Failure of empirical treatment for non-ESBL- and ESBL-producing E. coli UTI (adjusted for age, sex, and resistance).
| Age and sex | 14-days HR (99% CI) | 30-days HR (99% CI) | ||
|---|---|---|---|---|
| nonESBL | ESBL | nonESBL | ESBL | |
| Pivmecillinam | Ref. | Ref. | Ref. | Ref. |
| Ciprofloxacin | 0.99 (0.81–1.21) |
3.72 (2.41–5.75)II |
0.89 (0.75–1.06) |
2.93 (1.94–4.45)II |
| Nitrofurantoin | 0.92 (0.76–1.12) |
0.59 (0.29–1.23) |
1.08 (0.92–1.25) |
0.89 (0.54–1.47) |
| Aminopenicillinsa | 2.13 (1.73–2.62)II |
2.64 (1.23–5.66)I |
1.96 (1.63–2.35)II |
2.28 (1.13–4.60)I |
| Sulfamethizole | 1.73 (1.61–1.84)II |
2.14 (1.62–2.83)II |
1.52 (1.43–1.61)II |
1.69 (1.31–2.18)II |
| Trimethoprim | 1.29 (1.06–1.56)II |
2.50 (1.26–4.96)II |
1.21 (1.03–1.43)I |
1.94 (1.03–3.69)I |
| Age, sex, and resistance | ||||
| Pivmecillinam | Ref. | Ref. | Ref. | Ref. |
| Ciprofloxacin | 0.68 (0.55–0.86)II |
1.40 (0.83–2.36) |
0.66 (0.54–0.81)II |
1.29 (0.79–2.13) |
| Nitrofurantoin | 0.93 (0.76–1.14) |
0.55 (0.24–1.26) |
1.10 (0.94–1.28) |
0.94 (0.55–1.58) |
| Aminopenicillinsa | 1.08 (0.86–1.36) |
0.73 (0.29–1.79) |
1.09 (0.89–1.34) |
0.67 (0.29–1.58) |
| Sulfamethizole | 1.02 (0.95–1.11) |
1.17 (0.85–1.63) |
1.01 (0.95–1.08) |
1.03 (0.76–1.38) |
| Trimethoprim | 1.01 (0.83–1.22) |
1.41 (0.70–2.83) |
1.01 (0.86–1.20) |
1.23 (0.64–2.35) |
Note: aAmoxicillin or pivampicillin. I p<0.01, II p<0.001.
Abbreviations: HR, hazard ratio for treatment failure; CI, confidence interval (Sensitivity analysis).