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. 2019 Jul;76(1):115–124. doi: 10.1016/j.eururo.2019.02.003

Fig. 2.

Fig. 2

Effect of adding prostate radiotherapy to ADT on survival by patient age at randomisation, performance status, clinical T stage, and Gleason sum score. Each filled square denotes the HR for each subgroup of men defined by, age at randomisation, performance status, clinical T stage, and Gleason sum score within each trial, with the horizontal lines showing the 95% confidence interval (CI). The size of the square is directly proportional to the amount of information contributed by a subgroup. Each filled circle denotes the HR for the interaction between the effect of radiotherapy and these subgroups for each trial, with the horizontal lines showing the 95% CI. The size of each circle is directly proportional to the amount of information contributed by a trial. The open circle represents a (fixed-effect) meta-analysis of the interaction HRs, with the horizontal line showing the 95% CI. ADT = androgen deprivation therapy; HR = hazard ratio; RT = radiotherapy.