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. 2019 May 29;116(24):12054–12059. doi: 10.1073/pnas.1905993116

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Activation of Gα subunit chimeras with noncognate C termini. (A) G_si, G_sq, and G_s12 chimeras fully restored cAMP accumulation in response to D₁R stimulation (10 μM SKF 81297) in cells lacking endogenous Gα_s family subunits (n = 4). (B) G_qs, G_qi, and G_q12 chimeras fully restored calcium release in response to M₃R stimulation (100 μM acetylcholine) in cells lacking endogenous Gα_q family subunits (n = 6). (C) G_qi but not G_qs and G_q12 chimeras fully restored calcium release in response to H₁R stimulation (100 μM histamine) in cells lacking endogenous Gα_q subunits (n = 4). Traces are averages of several experiments, and data points represent independent experiments. Pertussis toxin S1 subunit (PTX) was coexpressed as indicated.