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. 2019 May 28;116(24):11754–11763. doi: 10.1073/pnas.1820990116

Fig. 4.

Fig. 4.

FBXO22 inhibits migration and invasion of breast cancer cells. MDA-MB-231 cells were treated with siRNA against FBXO22 or transfected with vector that expresses HA-FBXO22. (A) Immunoblot analyses confirmed FBXO22 depletion or overexpression. The levels of HDM2, MMP-9, and MMP-2 are also shown. The siRNA-treated or HA-FBXO22–expressing cells were examined for changes in migration (B) or invasion (C). Data are shown as means ± SD (three biological replicates; **P < 0.01). (D) Effects of FBXO22/HDM2 double KD on cell migration and invasion. FBXO22/HDM2 double KD suppresses the ability of FBXO22 KD cells to promote cell migration and invasion in MBA-MD-231 cells. Quantification is shown. Data are shown as means ± SD (three biological replicates). Western blots and images of cell migration or invasion are shown in SI Appendix, Fig. S12.