Fig. 6.

(A and B) Low FBXO22 expression is correlated with worse breast cancer survival. FBXO22 expression was examined in a total of 410 human breast carcinoma tissues, and statistical analysis of the relationship between FBXO22 expression and survival was performed as described in SI Appendix, Methods. Kaplan–Meier curves are shown to correlate low FBXO22 expression with worse 5-y overall (A) and disease-specific (B) survival in breast cancer patients. Cum., cumulative. (C) Low FBXO22 expression is correlated with high HDM2 expression in human breast cancer. A total of 407 human breast cancer samples were analyzed for expression levels of FBXO22 and HDM2, which were quantified and expressed by IRS as described in SI Appendix, Methods. Graph shows inverse correlation between expression of FBXO22 and HDM2 in 407 human breast cancer samples. (D) Summary of proposed SCF^FBXO22 biological roles. A diagram is presented to summarize the biological roles and pathways impacted by SCF^FBXO22 based on data shown in this work and in the literature. The Discussion includes a detailed description.