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Scenario of GRC origin and evolution. A proto-GRC forms due to duplication (Ctl-D) of a microchromosome likely containing genes involved in germ cell development. Copies of unique somatic cell sequences and repetitive elements invade the GRC (Ctl-C+Ctl-V). Divergence of GRCs in different songbird lineages occurs due to amplification and deletion (Del) of their sequences.
