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. 2019 May 28;116(24):11590–11595. doi: 10.1073/pnas.1902925116

Fig. 5.

Fig. 5.

Female pups of the PA group fed a low-fat diet (LFD) have higher liver lipid content at PND105. (A) H&E staining of livers (width of each field = 890 µm) showed no difference in lipid content at PND21. At PND105, female pups of the PA group showed visible changes in hepatic lipid content in response to postweaning feeding of a high-fat diet (HFD), compared with an LFD. At PND105, female pups of the PA group had an accumulation of lipid droplets near the portal triads, compared with female pups of the CA group, when postweaning offspring were fed the LFD. (B) At PND105, H&E staining of livers of female pups fed the LFD (width of each field in the top, middle, and bottom rows is 1,330, 890, and 230 µm, respectively) revealed that female pups of the PA group accumulated more adipose tissue in livers, compared with those of the CA group.