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. 2019 May 20;38(12):e101494. doi: 10.15252/embj.2019101494

Figure EV2. Secreted Aβ profiles in cell‐based thermoactivity assays.

Figure EV2

Aβ profiles (% contribution of individual Aβ37, Aβ38, Aβ40, Aβ42, and Aβ43 peptides to the total Aβ levels (Aβ37 + 38 + 40 + 42 + 43)) in the conditioned medium collected from WT or mutant (NCT) MEF cells lines co‐expressing WT or mutant APPC99 substrates, subjected to temperature challenge, were assayed by ELISA. The contribution of the Aβ43 peptides to the secreted Aβ pool is < 1% for the WT or mildly destabilizing FAD mutants (V89L and R269H). Data are represented as mean ± SD, N ≥ 3.