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. 2019 Apr 26;38(12):e102099. doi: 10.15252/embj.2019102099

Figure 5. BASCs continuously contribute to homeostatic renewal of the bronchioalveolar epithelium.

Figure 5

  1. Schematic depiction of the strategy to trace BASCs and descendants via the split‐tTA system.
  2. Quantification of β‐gal+ cells in FACS‐purified AT2 and Club cell fractions isolated from 3‐month‐old BASC v‐race mice (mean ± SD, n = 3) and example of β‐galactosidase label distribution in lung sections. Scale bar: 100 μm.
  3. BASCs emerge at early postnatal stages and contribute to epithelial turnover throughout life. β‐galactosidase staining of lung sections derived from BASC v‐race animals collected at indicated time points. Arrow highlights β‐gal+ cell at P6. Scale bar: 200 μm.

Source data are available online for this figure.