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. 2019 Apr 26;38(12):e102099. doi: 10.15252/embj.2019102099

Figure 7. BASCs expand in response to bronchiolar injury and are removed by IV infection.

Figure 7

  1. β‐galactosidase and H&E staining of lung sections from control (non‐infected) and injured BASC viewer mice 7 days post‐infection (7 dpi) with influenza virus. Scale bar: 200 μm.
  2. Abundance of β‐gal+ cells in control (non‐infected) and injured (7 dpi) BASC viewer animals. Data depicted as mean ± SD, n = 4, *P = 0.0286 (Mann–Whitney test), TB, terminal bronchiole.
  3. Club cell depletion/recovery after naphthalene treatment. Microscopic imaging of epifluorescence in lung sections from control and injured BASC viewer animals isolated 3, 7, and 21 days post‐naphthalene (dpn). Blue: DAPI. Scale bar: 200 μm.
  4. β‐galactosidase staining of lung sections from control and injured BASC viewer animals 3, 7, and 21 days post‐naphthalene (dpn). Scale bar: 200 μm.
  5. Abundance of β‐gal+ cells in control and injured BASC viewer animals. The percentage of terminal bronchioles containing 0, 1, 2, 3, 4, ≥ 5 β‐gal+ cells is shown. Data depicted as mean ± SD, n = 3.

Source data are available online for this figure.