Table 1.
Assignment of likely TPMT and NUDT15 phenotypes based on genotypes
| Assignment of likely TPMT phenotypes based on genotypes | ||
|---|---|---|
| Likely Phenotype | Genotypes | Examples of diplotypes |
| Normal metabolizer | an individual carrying normal function alleles | *1/*1 |
| Intermediate metabolizer | an individual carrying one normal function allele PLUS one no function allele | *1/*2, *1/*3A, *1/*3B, *1/*3C, *1/*4 |
| Possible Intermediate metabolizer | an individual carrying one uncertain/unknown function allele PLUS one no function allele | *2/*8, *3A/*7 |
| Poor metabolizer | an individual carrying two no function alleles | *3A/*3A, *2/*3A, *3A/*3C, *3C/*4, *2/*3C, *3A/*4 |
| Indeterminate | An individual carrying two uncertain/unknown
function alleles OR one normal function allele plus one uncertain allele function allele |
*6/*8 *1/*8 |
| Assignment of likely NUDT15 phenotypes based on genotypes | ||
| Normal metabolizer | an individual carrying two normal function alleles | *1/*1 |
| Intermediate metabolizer | an individual carrying one normal function allele PLUS one no function allele | *1/*2, *1/*3 |
| Possible Intermediate metabolizer | an individual carrying one uncertain function allele PLUS one no function allele | *2/*5, *3/*6 |
| Poor metabolizer | an individual carrying two no function alleles | *2/*2, *2/*3, *3/*3 |
| Indeterminate | one normal function allele PLUS one uncertain
function allele OR two uncertain function alleles |
*1/*4,
*1/*5 *4/*5, *5/*6 |