Table 1. Overview of aeQTL findings in DLPFC tissue.
| SNP | Pos | Gene | Dist (Kb) | Dist rank | Ref/Alt | Direction aeQTL/eQTL | aeQTL P | eQTL P (7) | Additional gene-SNP evidence | tx-SNPs | Reads | Individuals per aeQTL group | Protein | Tissue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs11210892 | chr1:44 | PTPRF | 12 | 1 | G/A | down/- | 1.40e-06 | 0.93 | - | 17 | 1500 | 129/287/121 | Protein Tyrosine Phosphatase | DLPFC |
| rs140505938 | chr1:150 | VPS45 | -8 | 1 | C/T | up/down | 0.0018 | 0.00249 | Js (P = 1.9e-16) | 5 | 87 | 19/74/21 | Vacuolar Protein Sorting 45 Homolog | DLPFC |
| ANP32e | -160 | 8 | C/T | down/- | 7.20e-10 | 0.337 | 8 | 670 | 49/311/54 | LANP-L | DLPFC | |||
| rs6670165 | chr1:177 | BRINP2 | 29 | 1 | C/T | down/- | 7.00e-13 | 0.0989 | Js (P = 2.2e-8) | 4 | 1600 | 76/250/88 | BRINP2 | DLPFC |
| rs7523273 | chr1:208 | CD46 | 8 | 1 | A/G | up/up | 1.00e-15 | 1.1e-33 | Js (P = 9.2e-38) | 9 | 250 | 137/109/118 | CD46 | DLPFC |
| rs6434928 | chr2:198 | HSPD1 | -47 | 3 | G/A | down/- | 0.00018 | 0.3 | Js (P = 3.3-14) | 6 | 260 | 136/186/119 | Chaperonin 60 | DLPFC |
| HSPD1 | -47 | 3 | G/A | down/- | 1.50e-05 | 0.76 | 6 | 370 | 70/147/68 | - | HIPPO | |||
| HSPe1-MOB4 | -60 | 4 | G/A | up/- | 5.10e-06 | 0.358 | - | 9 | 51 | 121/128/113 | Chap. 10, Mps One Binder Kinase Activator-Like 3 | DLPFC | ||
| rs2535627 | chr3:53 | SPCS1 | 103 | 6 | T/C | down/- | 0.00000003 | 0.142 | - | 3 | 230 | 116/119/98 | Signal Peptidase Complex Subunit 1 | DLPFC |
| NeK4 | 40 | 4 | T/C | up/up | 1.30e-05 | 0.0000015 | Js (P = 1.3e-8) | 9 | 44 | 134/153/128 | NIMA Related Kinase 4 | DLPFC | ||
| rs9841616 (chr3_180594593_I) | chr3:181 | DNAJC19 | -107 | 2 | D/I | up/- | 0.0014 | 0.926 | - | 2 | 54 | 113/17/124 | Mito. Inner membr. translocase subunit TIM14 | DLPFC |
| rs10043984 | chr5:138 | FAM53C | 27 | 2 | C/T | down/- | 0.00046 | 0.432 | Js (P = 5.6e-06) | 9 | 99 | 94/239/82 | FAM53C | DLPFC |
| rs111896713 (chr5_140143664_I) | chr5:140 | ZMAT2 | 58 | 2 | D/I | down/up | 5.60e-20 | 0.000000197 | Js (P = 2.2e-8) | 2 | 250 | 155/32/129 | Zinc finger matrin-type protein 2 | DLPFC |
| ZMAT2 | 58 | 2 | D/I | down/down | 2.20e-08 | 0.048 | 2 | 180 | 94/30/73 | Zinc finger matrin-type protein 2 | HIPPO | |||
| IK | 102 | 7 | D/I | down/up | 0.0005 | 0.012 | - | 5 | 150 | 91/118/70 | Cytokine IK | DLPFC | ||
| NDUFA2 | 116 | 8 | D/I | down/down | 4.20e-11 | 0.00596 | Rg (P = 2.2e-5) | 2 | 76 | 129/77/96 | Ubiquinone Oxidoreductase Sub-u. A2 | DLPFC | ||
| rs1339227 | chr6:73 | RIMS1 | 43 | 1 | C/T | down/- | 0.0013 | 0.128 | - | 21 | 440 | 120/338/103 | Reg. Synaptic Membr. exocytosis 1 | DLPFC |
| rs11191419 | chr10:105 | AS3MT-BORCS7 | -2 | 1 | T/A | up/up | 6.40e-20 | 1.88e-25 | Rg (P = 2.6e-5), Js (P = 2.0e-59) | 20 | 130 | 140/132/143 | Arsenite Methyltransferase | DLPFC |
| AS3MT-BORCS7 | -2 | 1 | T/A | up/up | 4.90e-08 | 5.10e-14 | 20 | 99 | 84/55/84 | Arsenite Methyltransferase | HIPPO | |||
| rs55833108 | chr10:105 | AS3MT-BORCS7 | 80 | 2 | G/T | down/- | 0.0022 | 0.0684 | - | 20 | 130 | 38/336/41 | Arsenite Methyltransferase | DLPFC |
| rs10791097 | chr11:131 | SNX19 | -28 | 1 | T/G | up/up | 9.50e-08 | 2.3e-10 | Js (P = 3.2e-29)) | 44 | 710 | 146/293/134 | Sorting Nexin 19 | DLPFC |
| SNX19 | -28 | 1 | T/G | up/up | 1.70e-06 | 0.024 | 44 | 1000 | 93/196/86 | Sorting Nexin 19 | HIPPO | |||
| rs12826178 | chr12:58 | LRP1 | 16 | 4 | G/T | down/- | 3.20e-05 | 0.383 | - | 32 | 130 | 24/413/23 | LDL Receptor Related Protein 1 | DLPFC |
| rs12887734 | chr14:104 | APOPT1 | 0 | 1 | G/T | down/down | 5.40e-44 | 1.12e-10 | Js (P = 3.0e-22) | 8 | 6300 | 119/57/109 | Apoptogenic 1 | DLPFC |
| CKB | 59 | 4 | G/T | down/- | 2.20e-07 | 0.617 | - | 3 | 9200 | 66/249/65 | Creatine Kinase B | DLPFC | ||
| PPP1R13B | -153 | 8 | G/T | down/down | 0.0006 | 0.0166 | - | 9 | 40 | 38/107/37 | Phosphatase 1 Regulatory Sub-u. 13B | DLPFC | ||
| rs56205728 | chr15:41 | BUB1B-PAK6 | 0 | 1 | G/A | down/down | 0.0014 | 0.049 | - | 38 | 1200 | 112/329/98 | Mitotic checkpoint ser/ Ser/thr-protein kinase | DLPFC |
| rs4702 | chr15:91 | FURIN | 0 | 1 | G/A | down/down | 2.70e-11 | 0.00175 | Fg (P = 1.0e-6) | 10 | 64 | 133/207/135 | Membrane Associated Receptor Prot. | DLPFC |
| rs12691307 | chr16:30 | FAM57B | -96 | 12 | A/G | up/up | 1.70e-07 | 0.00815 | Js (P = 5.1e-6)) | 4 | 310 | 125/157/140 | FP1188 | DLPFC |
| rs8044995 | chr16:68 | PRMT7 | -156 | 7 | G/A | down/down | 0.00081 | 1.96e-05 | Rg (P = 2.2e-5), Js (P = 1.0e-10)) | 9 | 530 | 82/265/95 | Protein Arginine Methyltransferase 7 | DLPFC |
| LCAT-SLC12A4 | 191 | 9 | G/A | down/- | 0.00039 | 0.358 | - | 11 | 18 | 53/98/66 | Lecithin-Cholesterol Acyltransferase, Solute Carrier Family 12 Member 4 |
DLPFC | ||
| rs8082590 | chr17:18 | TOM1L2 | 186 | 8 | G/A | down/down | 6.70e-12 | 0.00161 | Js (P = 3.8e-05)) | 24 | 390 | 133/139/146 | Target Of Membrane Trafficking Prot. | DLPFC |
| rs2905426 | chr19:19 | GATAD2A | -98 | 4 | G/T | down/down | 9.70e-05 | 1.82e-10 | Js (P = 1.1e-8) | 15 | 82 | 127/147/133 | GATA Zinc Finger Domain Contain. 2A | DLPFC |
| HAPLN4 | 109 | 5 | G/T | up/- | 6.70e-19 | 0.979 | - | 12 | 240 | 100/153/102 | Brain Link Protein 2 | DLPFC |