Table 1. Biomarkers levels at post-CPB1 and post-CPB2 according to mechanical ventilation, inotropic support and invasive bacterial infection.
Data expressed by median (interquartile range) and compared with Mann-Whitney test.
| post-CPB1 | post-CPB2 | |||||
| Biomarker levels | MV n = 48 | Non-MV n = 63 | p-value | MV n = 38 | Non-MV n = 73 | p-value |
| PCT (ng/ml) | 0.37 (0.06–1.20) | 0.26 (0.09–0.80) | 0.782 | 0.23 (0.06–1.16) | 0.34 (0.13–0.88) | 0.580 |
| Pro-ADM (nmol/L) | 1.35 (0.99–2.02) | 0.92 (0.73–1.16) | 0.000 | 1.34 (0.98–1.94) | 0.91 (0.75–1.15) | 0.000 |
| Pro-ANP (pmol/L) | 299.80 (147.10–476.58) | 124.50 (89.25–230.05) | 0.000 | 301.02 (144.95–464.45) | 124.50 (86.97–221.30) | 0.000 |
| Biomarker levels |
Inotropic support n = 34 |
Non-inotropic support n = 77 | p-value | Inotropic support n = 28 | Non-inotropic support n = 83 | p-value |
| PCT (ng/ml) | 0.42 (0.07–3.10) | 0.28 (0.23–0.79) | 0.283 | 0.38 (0.70–2.68) | 0.31 (0.66–0.80) | 0.590 |
| Pro-ADM (nmol/L) | 1.36 (0.99–2.69) | 0.96 (0.74–1.27) | 0.000 | 1.50 (1.03–2.70) | 0.96 (0.74–1.25) | 0.000 |
| Pro-ANP (pmol/L) | 282.25 (110.67–403.95) | 146.40 (98.65–270.20) | 0.010 | 318.55 (170.90–513.07) | 140.45 (95.45–241.50) | 0.000 |
| Biomarker levels |
IBI n = 17 |
Non-IBI n = 94 |
p-value |
IBI n = 17 |
Non-IBI n = 94 | p-value |
| PCT (ng/ml) | 1.98 (0.275–5.53) | 0.23 (0.07–0.75) | 0.020 | 3.89 (2.03–6.00) | 0.41 (0.071–0.63) | 0.000 |
| Pro-ADM (nmol/L) | 1.44 (0.94–2.21) | 1 (0.78–1.45) | 0.036 | 1.84 (1.23–2.68) | 0.95 (0.75–1.15) | 0.000 |
| Pro-ANP (pmol/L) | 186.10 (137.70–350.02) | 174.90 (104.55–341.30) | 0.502 | 244.20 (138.95–507.7) | 148.80 (92.97–326.05) | 0.000 |
MV: mechanical ventilation, IBI: invasive bacterial infection, PCT: procalcitonin, pro-ADM: pro-adrenomedulin, Pro-ANP: pro-atrial natriuretic peptide, CPB: cardiopulmonary bypass.