Table 2. Area under the curve for pro-ADM and pro-ANP measured at post-CPB1 and post-CPB2, and PRISM III value at post-CPB1 with regard to mechanical ventilation requirement.
| Mechanical ventilation requirement | |||||||
|---|---|---|---|---|---|---|---|
| Variables | AUC | p (CI 95%) | Cut-off | Sn % (CI 95%) |
Sp % (CI 95%) |
PPV % (CI 95%) |
NPV % (CI 95%) |
| Pro-ADM CPB1 | 0.721 | 0.006 (0.568–0.845) |
> 1.223 | 69.50 (36.40–79.30) | 86.96 (76.44–97.20) |
80.21 (54.16–95.17) |
78.94 (60.24–91.60) |
| Pro-ANP CPB1 | 0.746 | 0.002 (0.589–0.881) |
> 215.3 | 69.55 (32.20–75.63) | 78.26 (56.35–92.55) | 70.87 (46.61–88.69) |
77.16 (57.07–90.98) |
| PRISM III | 0.600 | 0.075 (0.497–0.697) |
> 2 | 65.9 (50.77–79.12) |
46.1 (32.20–60.53) |
48.23 (29.08–67.77) |
64.06 (39.21–84.37) |
| Surgical time | 0.697 | 0.003 (0.576–0.800) |
>160 | 62.9 (42.4–80.6) |
75.0 (59.7–86.8) |
60.7 (40.6–78.5) |
76.7 (61.2–88.4) |
| Bypass time | 0.767 | <0.001 (0.680–0.841) |
>80 | 63.8 (48.5–77.3) |
79.7 (68.3–88.4) |
68.2 (52.4–81.4) |
76.4 (64.9–85.6) |
| Cross clamp time | 0.776 | <0.001 (0.687–0.849) |
>47 | 66.7 (51–80) |
76.1 (64.1–85.7) |
65.2 (49.8–78.6) |
77.3 (65.3–86.7) |
| Ultrafiltrate volume | 0.538 | 0.517 (0.435–0.639) |
<450 | 61.5 (44.6–76.6) |
50 (36.8–63.2) |
44.4 (30.9–58.6) |
66.7 (50.9–80.1) |
| Pro-ADM CPB2 | 0.738 | <0.001 (0.642–0.820) |
> 1.01 | 72.92 (58.20–84.72) |
64.81 (50.68–77.35) | 51.85 (27.57–75.51) | 82.16 (58.04–95.63) |
| Pro-ANP CPB2 | 0.753 | <0.001 (0.658–0.833) |
> 172.5 | 70.83 (55.91–83.02) |
62.96 (48.74–75.71) |
49.84 (25.89–73.85) |
80.59 (56.26–94.83) |
MV: mechanical ventilation, CPB: cardiopulmonary bypass, pro-ADM: pro-adrenomedullin, pro-ANP: pro-atrial natriuretic peptide, PRISM III: Pediatric Risk Score Mortality III, AUC: area under the curve, CI: confidence interval, Sn: sensitivity, Sp: specificity, PPV: positive predictive value, NPV: negative predictive value.