Table 3. Area under the curve (AUC) for the three biomarkers with respect to the presence of invasive bacterial infection.
Data expressed by median (interquartile rang).
| post-CPB1 | |||||||
| Biomarker | AUC | p (CI 95%) | Cut off | Sn % (CI 95%) | Sp % (CI 95%) | PPV (%) | NPV (%) |
| PCT (ng/ml) | 0.643 | 0.017 (0.549–0.729) |
> 0.1 | 69.70 (53.9–82.8) | 41.89 (30.5–53.9) | 17.80 (1.83–53.32) |
96.28 (40.83–99.93) |
| Pro-ADM (nmol/L) | 0.726 | <0.001 (0.633–0.806) |
> 0.90 | 80.95 (65.9–91.4) | 47.83 (35.6–60.2) | 21.89 (2.70–59.69) | 93.29 (50.43–99.99) |
| Pro-ANP (pmol/L) | 0.622 | 0.023 (0.525–0.712) |
> 140 | 71.43 (55.4–84.3) | 49.28 (37.0–61.6) | 20.28 (2.19–58.09) |
90.52 (47.25–99.95) |
| post-CPB2 | |||||||
| Biomarker | AUC | p (CI 95%) | Cut off | Sn % (CI 95%) | Sp % (CI 95%) | PPV (%) | NPV (%) |
| PCT (ng/ml) | 0.896 | 0.001 (0.821–0.947) |
> 1.9 | 78.95 (62.7–90.4) | 95.52 (87.5–99.1) | 79.09 (6.40–99.98) |
96.17 (70.78–99.99) |
| Pro-ADM (nmol/L) | 0.795 | <0.001 (0.701–0.870) |
> 1.1 | 77.78 (60.8–89.9) | 63.93 (50.6–75.8) | 28.03 (3.49–70.51) |
94.09 (58.10–99.99) |
| Pro-ANP (pmol/L) | 0.727 | < 0.001 (0.627–0.812) |
> 140.0 | 71.43 (55.4–84.3) | 47.83 (35.6–60.2) | 19.83 (2.06–57.64) |
90.26 (46.96–99.95) |
CPB: cardiopulmonary bypass, AUC: area under the curve, CI: confidence interval, Sn: sensibility, Sp: specificity, PPV: positive predictive value, NPV: negative predictive value, PCT: procalcitonin, pro-ADM: pro-adrenomedullin, Pro-ANP: pro-atrial natriuretic peptide.