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DHβE antagonism can be overcome by increasing the acetylcholine concentration
| Receptor | [DHβE] (μm) | [ACh] (μm) | Percent of control |
|---|---|---|---|
| α3β2 | 1 | 10 | 21.5 ± 5.0 |
| α3β2 | 1 | 1000 | 96.1 ± 1.1 |
| α3β4 | 30 | 100 | 40.4 ± 9.9 |
| α3β4 | 30 | 10,000 | 95.9 ± 1.9 |
| α3β2,T59K | 10 | 30 | 17.2 ± 5.8 |
| α3β2,T59K | 10 | 3000 | 85.5 ± 1.8 |
ACh-induced current in the presence of DHβE is presented as a percentage of the control response to ACh alone (mean ± SD of 3–6 oocytes).
