Fig. 6.

Effects induced by DAGO on the synchronous activity recorded in the entorhinal cortex and CA3 area during application of 4AP. Note in A that during DAGO, both GABA-mediated field potentials and ictal discharges disappear, whereas interictal discharges propagating to the hippocampus proper appear in the entorhinal cortex. This effect is accompanied by a decrease in the rate of occurrence of hippocampal interictal discharges. B, Plot of the changes induced by DAGO on the rate of occurrence of GABA-mediated potentials, ictal discharges, and interictal events in five slices.