Table 1.

mGluR timing model simulation parameters

Parameter	Value	Reason for choice
Bmax	Variable	See Discussion in text
k1	50	Steady-state fromThomsen et al. (1993); assume fast reaction
k2	80
k3	0	Assume slow enough to ignore
k4	0.1	Assume forward reaction is slow (cf. Berstein et al., 1992; Casey et al., 1990); total PKC inact
k5	1
k6	20
Gmax	1	Arbitrary
k7	4	Chosen to produce latencies in observed CR response range (cf. Wang et al., 1995)
k8	40
k9	8
Imax	1	Arbitrary
Dmax	1	Arbitrary
k10	5	KD∼6 μm (Nishizuka, 1988); rate set for proper inactivation
k11	30
Cmax	6	More PKC than calcineurin
k12	60	Steady-state fit to Bezprozvanny et al. (1991); rate of reactions fit to fast desensitization data of Levitan et al. (1993)
k13	48.6
k14	7.55
k15	0.42
n	1.65
k16	2	Chosen to produce a [Ca2+]cyt transient of appropriate duration and amplitude
k17	8
k18	25
T	293°K	Eilers et al., 1995
[Ca2+]ER	1 mm	Baumann et al., 1991
[Na+]cyt	8 mm	Eilers et al., 1995
[Na+]ext	125 mm	Eilers et al., 1995
[Ca2+]ext	2 mm	Eilers et al., 1995
k19	100	Set amplitude of depolarizations
k20	10	Set rate of decay of potential
τ1	0.025	Assume [cGMP] signal has rapid onset and decay
τ2	0.005
k21	1	Set amplitude and duration of N
k22	12	Set amplitude and duration of N
Nmax	2	Less calcineurin than PKC
k23	2	Set rate of learning
k24	0.4	Set rate of extinction
gmax	600	Need large$\overline{g}$ to hyperpolarize