Fig. 5.
CP55,940 is a partial agonist. A, The synthetic cannabinoid CP55,940 (100 nm) partially reverses 100 nm Win 55,212-2 inhibition of low [Mg2+]o-induced [Ca2+]i spiking. Application of Win 55,212-2 and CP55,940 is indicated by thebars, and 0.1 mm[Mg2+]o buffer was superfused throughout the recording. B, Histogram summarizing reduction in [Ca2+]i spike frequency produced by Win 55,212-2 and CP55,940 (n = 8). Error bars represent SEM. Asterisks indicate significantly different from Win 55,212-2 application alone;p < 0.01 (ANOVA with Bonferroni post-test).